UK fraud office weighs prosecutions of Barclays

El frontis de una sucursal bancaria de Barclay's en el centro de Londres el viernes 28 de junio del 2012. Barclays PLC y sus subsidiarias pagar?n multas de 453 millones de d?lares por haber manipulado las tasas de inter?s crediticias. El presidente del Barclays Marcus Agiusanunci? el lunes su renuncia despu?s de aceptar responsabilidad de haber dado falsas tasas pr?stamo interbancario, lo cual le ha costado al banco multas trasatl?nticas de 453 millones de d?lares. (Foto AP Photo/Lefteris Pitarakis)

El frontis de una sucursal bancaria de Barclay's en el centro de Londres el viernes 28 de junio del 2012. Barclays PLC y sus subsidiarias pagar?n multas de 453 millones de d?lares por haber manipulado las tasas de inter?s crediticias. El presidente del Barclays Marcus Agiusanunci? el lunes su renuncia despu?s de aceptar responsabilidad de haber dado falsas tasas pr?stamo interbancario, lo cual le ha costado al banco multas trasatl?nticas de 453 millones de d?lares. (Foto AP Photo/Lefteris Pitarakis)

This undated file photo made available by Barclays Bank Monday July 2, 2012 shows the Chairman of United Kingdom-based Barclays bank Marcus Agius in London. The chairman of Barclays announced his resignation Monday July 2, 2012 after accepting responsibility for a price-fixing scandal that saw the bank slapped with trans-Atlantic fines of $453 million. Last week, U.S. and British agencies imposed the fines on Barclays for submitting false data on interbank borrowing rates between 2005 and 2009. The bank's executives have been under fire since then and the calls are growing for chief executive Bob Diamond to quit too. (AP Photo/Barclays Bank/VisualMedia, HO)

LONDON (AP) ? Britain's Serious Fraud Office says it is considering the possibility of criminal prosecutions for a financial market manipulation scandal that involves Barclays bank.

Barclays has been fined $453 million by U.S. and British agencies for providing false data on borrowing costs between 2005 and 2009.

The Serious Fraud Office said Monday that the issues are complex but it hopes to decide within a month on whether prosecutions are possible.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-07-02-Britain-Barclays%20Chairman/id-7e68b755afa943c5ad26274407d393e1

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Israeli PM 'sends letter to Egypt's Morsi'

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Source: http://news.yahoo.com/israeli-pm-sends-letter-egypts-morsi-064433377.html

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An error-eliminating fix overcomes big problem in '3rd-gen' genome sequencing

ScienceDaily (July 1, 2012) ? A quantitative biologist at Cold Spring Harbor Laboratory (CSHL) and collaborators have published results of experiments that demonstrate the power of so-called single-molecule sequencing, which was recently introduced but whose use has so far been limited by technical issues.

The team, led by CSHL Assistant Professor Michael Schatz and Adam Phillippy and Sergey Koren of the National Biodefense Analysis and Countermeasures Center and the University of Maryland (UMD), has developed a software package that corrects a serious problem inherent in the newest sequencing technology: the fact that every fifth or sixth DNA "letter" it generates is incorrect. The high error rate is the flip side of the new method's chief virtue: it generates much longer genome "reads" than other technologies currently used, up to 100 times longer, and thus can provide a much more complete picture of genome structure than can be obtained with current, "2^nd-gen" sequencing technology.

Using mathematical algorithms, Schatz and the team have preserved the great advantage of the "3^rd-gen" method while all but eliminating its chief flaw. They have reduced the error rate from about 15% or greater to less than one-tenth of one percent. This mathematical "fix" -- which has been published in open-source code to the World Wide Web -- greatly increases the practical utility of 3^rd-gen sequencing for the entire biomedical research community. The team demonstrates the breadth of potential applications of single-molecule sequencing by applying their fix to sequencing tasks ranging from the tiny bacteriophage virus at one end of the difficulty scale to the large and vastly more complex genome of the parrot, at the other. The parrot genome is more than a third the size of the human genome and is published online July 1 with the team's paper in Nature Biotechnology. The parrot sequence is "far superior to that of any previously sequenced bird genome," Schatz says.

To understand why it is better is to appreciate the advantages of 3^rd-gen sequencing. The main advantage has to do with the average length of each "read" (i.e., genome segments read by a sequencer). The individual sequences are assembled into "contigs" -- shorthand for contiguous sequences -- much the way pieces in a jigsaw puzzle are assembled. In currently used 2^nd-gen technology, the contigs are very small, and are massively redundant. A "consensus" version of each segment, representing the results of many layered reads, tends to be extremely accurate. But the small size of puzzle pieces prevents accurate assembly of certain genome portions, like those containing long repetitive sequences.

Obtaining superior versions of complete genomes was the objective that motivated Schatz and his collaborators, who also include HHMI Investigator Erich D. Jarvis of Duke University and CSHL Professor W. Richard McCombie, a sequencing pioneer, among others.

Combining the best of both generations

With single-molecule sequencing, the assembled contigs are much longer -- affording a much better picture of relatively larger genome segments, including those occupied by lengthy repeats. This is what Schatz and his team wanted to preserve, while at the same time boosting the error-free rate. They did so by effectively taking the best of both 2^nd- and 3^rd-gen technologies.

"We call our approach 'hybrid error correction,'" Schatz explains.

The team's major insight was to take advantage of the long-read data offered by a 3^rd-gen machine like that used in their experiments, a Pacific Biosciences RS sequencer, and mixing in highly accurate short reads obtained from a separate 2^nd-gen sequencer. The two data types were run through an open-source genome assembly program called Celera Assembler to generate a clean final assembly that has proven 99.9% error-free and composed of contigs whose median size is at least double that obtainable with 2^nd-gen "short-read" sequencers. Contig sizes are expected to increase appreciably in subsequent iterations of the hybrid approach as single molecule long-read sequencing improves.

High-quality genome assemblies are especially important for genome annotation and comparative genome analyses. Many microbial genome analyses depend on finished genomes, but their cost is prohibitive using older technologies. High-quality analysis of the genomes of higher organisms depends upon continuous sequences that capture long stretches of DNA that spell out genes. Discoveries in recent years of spontaneously occurring structural changes in genomes called copy number variations -- such as those made by CSHL Professor Mike Wigler and his team in their research on schizophrenia and autism -- make clear the importance of being able to obtain clean and accurate pictures of the entire genomes of affected individuals.

With hybrid error correction, Schatz and his colleagues have "demonstrated that high error rates associated with long reads need not be a barrier to genome assembly," he summarizes. "High-error long reads can be efficiently assembled in combination with complementary short reads to produce assemblies not previously possible."

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Story Source:

The above story is reprinted from materials provided by Cold Spring Harbor Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Sergey Koren, Michael C Schatz, Brian P Walenz, Jeffrey Martin, Jason T Howard, Ganeshkumar Ganapathy, Zhong Wang, David A Rasko, W Richard McCombie, Erich D Jarvis, Adam M Phillippy. Hybrid error correction and de novo assembly of single-molecule sequencing reads. Nature Biotechnology, 2012; DOI: 10.1038/nbt.2280

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120701191609.htm

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The Pogues - The Band Played Waltzing Matilda (Americablog)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/236534724?client_source=feed&format=rss

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Looking Back at Tom Cruise and Katie Holmes's Wedding Pictures

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It was less than six years ago that Tom Cruise and Katie Holmes got married in a fairy-tale ceremony in Italy. The couple rented out Odescalchi Castle, near Rome, to say their vows before family and famous friends like Jennifer Lopez and Marc Anthony, David and Victoria Beckham, as well as Will and Jada Pinkett Smith. For the Nov. 18, 2006 nuptials, Tom and Katie had a then 7-month-old Suri Cruise by their sides, along with Tom's children from his marriage to Nicole Kidman, 11-year-old Connor and 13-year-old Isabella. The bride wore Armani to say her "I dos." Today, though, we learned that Tom and Katie are divorcing. As we process the news, click through to see their special day. View Slideshow ?

Continue to full source

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Today's Inspirational Quote

"The precondition to freedom is security."
- Rand Beers

"You cannot believe in God until you believe in yourself."
- Swami Vivekananda

"Be who you are and be that well."
- Saint Francis de Sales

"You have to dream before your dreams can come true."
- Abdul Kalam

Source: http://www.clickcelebrity.com/59946-looking-back-at-tom-cruise-and-katie-holmess-wedding-pictures.html

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Get Ready for London Anime Con this Weekend!

Are you all packed and ready for London Anime Con this weekend? Taking place at The Rocket Complex, Holloway Road, it has been confirmed that even if you missed the online-sales deadline, there will be tickets available on the door due to increased capacity - so don't worry about not being able to get in and make sure to go along! At just ?10 for an entire day and night until 1am in the morning, it's excellent value for money.

Check out travel information and how to get to the event here, and you can browse the London Anime Con website and view what guests and events it has to offer at http://www.londonanimecon.com

?
To get an idea of the event, it's atmosphere and what there is, why not check out this music-video that was created by the band Superpowerless at the last London Anime Con.

Source: http://news.mmosite.com/content/2012-06-29/get_ready_for_london_anime_con_this_weekend.shtml

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American Worldwide Empire

In an alternate history the United States, during WW2, elected a charismatic (and secretly evil) president who promised to end WW2 for good. The allies were getting hit very hard and needed the United States help or else they would be lose for sure. After entering the war near its end, it wasn't just two atomic bombs dropped, but in fact they targeted multiple locations in the axis powers all at once as a shock and awe campaign. With the axis annihilated and the allies in bad shape, they were all forced into a treaty which allowed the US large territorial expansion, among other benefits. Some countries tried to resist, such as Russia, but they too were targeted with nuclear weapons and were forced under the control of the US. A large war was fought soon after with most of the countries united together, and although they put up a good fight they didn't succeed. With that defeat, the US was now the first worldwide empire.

Time went on and guerilla warfare was used, but all were quickly crushed....until now. Japanese scientists managed to secretly construct powerful suits and weaponry modeled after and improved on stolen US technology (which is now futuristic). With the best fighters in these suits leading the way, and with a much more unified organization, they began their largest counterattack yet. But can they really stop an empire powerful enough to hold the entire world under it's control? We're about to find out.

So is any of you interested?

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/iI7cdRD7laY/viewtopic.php

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